Need for a simpler method for ICP measurement
Several neurological conditions are associated with raised intracranial pressure. Traumatic Brain Injury alone affects nearly 70 million people each year worldwide. Today ICP is measured invasively by inserting a pressure sensor through a cranial burr hole. The invasive procedure is performed by highly specialized personnel and carries along a high cost and risk of infection and bleeding. Early diagnostics and treatment is important. Nisonic has developed the technology to enable non-invasive detection of increased intracranial pressure.
Our Story
Dr. Llewellyn Padayachy introducing Nisonic’s non-invasive method to detect increased intracranial pressure using ultrasound
Ultrasound imaging for non-invasive detection of ICP
Nisonic has developed a novel method for measuring the static and dynamic properties of the optic nerve sheath to detect the patient’s intracranial pressure. The method has been developed by engineers at SINTEF, Trondheim, Norway and neurosurgeons at Red Cross War Memorial Children’s Hospital, University of Cape Town in South Africa. The ultrasound system consists of a dedicated probe for transorbital ultrasound imaging together with advanced machine learning algorithms for automatic measurements and guiding.
Fast and simple
A few minutes per eye
No equipment calibration
Easy to use
Guided probe positioning
Automatic measurement
Better patient care
Enables earlier treatment
Reduced invasive interventions
The Company
Nisonic AS is a medical device company developing products for non-invasive detection of intracranial pressure (ICP) using ultrasound imaging and machine learning. The company was established in 2017 in Trondheim, Norway, and is a spin-out from SINTEF Medical Technology. Ultrasound experts and neurosurgeons have been working together since 2013 combining world leading ultrasound technology with clinical expertise to develop the new method for detecting intracranial pressure.
Our timeline
2013-2015
Research & concept
Concept developed by neurosurgeons and researchers in Norway and South Africa
2016-2018
Product design/Proof of concept
Clinical studies / 2 publications
Pulsatile Dynamics of the Optic Nerve Sheath and Intracranial Pressure: An Exploratory In Vivo Investigation
Noninvasive Transorbital Assessment of the Optic Nerve Sheath in Children: Relationship Between Optic Nerve Sheath Diameter, Deformability Index, and Intracranial Pressure
Patent application filed
Dedicated transducer design
Software prototype
Industrial partnerships
2019-2020
Development/Clinical trial
Clinical study at Oslo University Hospital Ullevål (ongoing)
Technology and product improvements
2021
First CE-marked product
Nisonic P-100 CE-marked May 2021
Our product
- Optimized transducer for transorbital ultrasound imaging
- Automatic measurements based on advanced machine-learning algorithms
- Guidance for accurate probe positioning
The Nisonic system is available in a limited number for hospitals doing research on ICP. We continue developing the system, and partners will be invited to our R&D program.
Contact usOur team
We are an interdisciplinary and experienced team in the intersection of technology and healthcare.
With leading competence within ultrasound technology we are collaborating closely with international neurosurgeons, clinicians and research institutes to enable better diagnostics and treatment.
Would you like to join our team?
Please send your CV and motivation to contact@nisonic.com
Our advisory board
Llewellyn Padayachy
Steve Biko Academic Hospital
Llewellyn (Chairman of SAB) is a neurosurgeon, currently serving as professor and head at the University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa. He is primarily a pediatric neurosurgeon with special interests in non-invasive diagnostic and minimally invasive surgical techniques and serves on the executive committees various international and local neurosurgical organisations. He has over a decade developed novel non-invasive diagnostic methods using ultrasound-based parameters for detection of ICP.
Eirik Helseth
MD, University of Bergen in 1985. PhD, University of Trondheim 1988. Postdoc at Dana Farber Cancer Institute, Harvard University in Boston 1988/1989. Board certified Neurosurgeon in 1996. Appointed professor in Neurosurgery, University of Oslo in 2004. Professor Helseth is an experienced neurosurgeon and researcher with special interest in brain tumors and neurotrauma.
Our partners
