Need for a simpler method for ICP measurement

Several neurological conditions are associated with raised intracranial pressure. Traumatic Brain Injury alone affects nearly 70 million people each year worldwide. Today ICP is measured invasively by inserting a pressure sensor through a cranial burr hole. The invasive procedure is performed by highly specialized personnel and carries along a high cost and risk of infection and bleeding. Early diagnostics and treatment is important. Nisonic has developed the technology to enable non-invasive detection of increased intracranial pressure.

Our Story

Dr. Llewellyn Padayachy introducing Nisonic’s non-invasive method to detect increased intracranial pressure using ultrasound

Ultrasound imaging for non-invasive detection of ICP

Nisonic has developed a novel method for measuring the static and dynamic properties of the optic nerve sheath to detect the patient’s intracranial pressure. The method has been developed by engineers at SINTEF, Trondheim, Norway and neurosurgeons at Red Cross War Memorial Children’s Hospital, University of Cape Town in South Africa. The ultrasound system consists of a dedicated probe for transorbital ultrasound imaging together with advanced machine learning algorithms for automatic measurements and guiding.

Fast and simple

A few minutes per eye
No equipment calibration

Easy to use

Guided probe positioning
Automatic measurement

Better patient care

Enables earlier treatment
Reduced invasive interventions

The Company

Nisonic AS is a medical device company developing products for non-invasive detection of intracranial pressure (ICP) using ultrasound imaging and machine learning. The company was established in 2017 in Trondheim, Norway, and is a spin-out from SINTEF Medical Technology. Ultrasound experts and neurosurgeons have been working together since 2013 combining world leading ultrasound technology with clinical expertise to develop the new method for detecting intracranial pressure.

Our timeline

Research & concept

Concept developed by neurosurgeons and researchers in Norway and South Africa

Product design/Proof of concept

Clinical studies / 2 publications

Pulsatile Dynamics of the Optic Nerve Sheath and Intracranial Pressure: An Exploratory In Vivo Investigation

Read more

Noninvasive Transorbital Assessment of the Optic Nerve Sheath in Children: Relationship Between Optic Nerve Sheath Diameter, Deformability Index, and Intracranial Pressure

Read more

Patent application filed

Dedicated transducer design

Software prototype

Industrial partnerships

Development/Clinical trial

Clinical study at Oslo University Hospital Ullevål (ongoing)

Technology and product improvements


First CE-marked product

Nisonic P-100 CE-marked May 2021

Our product

  • Optimized transducer for transorbital ultrasound imaging
  • Automatic measurements based on advanced machine-learning algorithms
  • Guidance for accurate probe positioning

The Nisonic system is available in a limited number for hospitals doing research on ICP. We continue developing the system, and partners will be invited to our R&D program.

Contact us
Not for sale in the US

Our team

We are an interdisciplinary and experienced team in the intersection of technology and healthcare.

With leading competence within ultrasound technology we are collaborating closely with international neurosurgeons, clinicians and research institutes to enable better diagnostics and treatment.


Would you like to join our team?
Please send your CV and motivation to

Our advisory board

Llewellyn Padayachy

Professor and Head Department of Neurosurgery
University of Pretoria
Steve Biko Academic Hospital

Llewellyn Padayachy

Professor and Head Department of Neurosurgery

Llewellyn (Chairman of SAB) is a neurosurgeon, currently serving as professor and head at the University of Pretoria, Steve Biko Academic Hospital, Pretoria, South Africa. He is primarily a pediatric neurosurgeon with special interests in non-invasive diagnostic and minimally invasive surgical techniques and serves on the executive committees various international and local neurosurgical organisations. He has over a decade developed novel non-invasive diagnostic methods using ultrasound-based parameters for detection of ICP.

Eirik Helseth

Professor and Senior Neurosurgeon
University of Oslo, Oslo University Hospital

Eirik Helseth

Professor and Senior Neurosurgeon

MD, University of Bergen in 1985. PhD, University of Trondheim 1988. Postdoc at Dana Farber Cancer Institute, Harvard University in Boston 1988/1989. Board certified Neurosurgeon in 1996. Appointed professor in Neurosurgery, University of Oslo in 2004. Professor Helseth is an experienced neurosurgeon and researcher with special interest in brain tumors and neurotrauma.

Our partners